Benign multiple sclerosis

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Definition, prevalence and predictive factors of benign multiple sclerosis

Background Multiple sclerosis (MS) is characterized by a great inter-individual variability in disease course and severity. Some patients experience a rather mild course, controversially called 'benign MS' (BMS). The usefulness of this entity in clinical practice remains unclear. Methods We performed a literature search in PubMed, Web of Science and Cochrane Library databases from November 19...

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Benign multiple sclerosis: aspects of cognition and neuroimaging.

The existence of a benign multiple sclerosis (BMS) form is a controversial subject. Recent studies of these patients reveal different levels of cognitive impairment, despite the apparent preservation of motor function. The objective of this study was to review and analyze a number of publications that discuss the general aspects of this disease form, such as the definition criteria, prevalence,...

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Global N-acetylaspartate declines even in benign multiple sclerosis.

BACKGROUND AND PURPOSE Neuro-axonal damage is a well known sequelae of MS pathogeneses. Consequently, our aim was to test whether the ∼20% of patients with MS exhibiting a clinically benign disease course also have minimal neural dysfunction as reflected by the global concentration of their MR imaging marker NAA. MATERIALS AND METHODS Q(NAA) was obtained with nonlocalizing whole-head (1)H-MR ...

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Rate of brain atrophy in benign vs early multiple sclerosis.

BACKGROUND Benign multiple sclerosis (MS) is defined by minimal or no disability after many years of observation, therefore a less degenerative disease process is suspected to be present in this subset of patients. OBJECTIVE To compare brain atrophy rates in patients with long-standing benign MS vs typical early MS. DESIGN A longitudinal prospective cohort study and a retrospective database...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 1999

ISSN: 0022-3050

DOI: 10.1136/jnnp.67.2.138